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Syk facilitates phagosome-lysosome fusion by regulating actin-remodeling in complement-mediated phagocytosis

Effective phagocytosis is crucial for host defense against pathogens. Macrophages entrap pathogens into a phagosome and subsequently acidic lysosomes fuse to the phagosome. Previous studies showed the pivotal role of actin-remodeling mediated by phosphoinositide-related signaling in phagosome format...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Tabata, Hiroyuki, Morita, Hiroyuki, Kaji, Hiroaki, Tohyama, Kaoru, Tohyama, Yumi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744523/
https://ncbi.nlm.nih.gov/pubmed/33328565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79156-7
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