Rab27a Negatively Regulates Phagocytosis by Prolongation of the Actin-coating Stage around Phagosomes

Rab27a, a Rab family small GTPase, is involved in the exocytosis of secretory granules in melanocytes and cytotoxic T-cells. Rab27a mutations cause type 2 Griscelli syndrome, which is characterized by immunodeficiency, including uncontrolled macrophage activation known as hemophagocytic syndrome. Ho...

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Main Authors: Yokoyama, Kunio, Kaji, Hiroaki, He, Jinsong, Tanaka, Chisato, Hazama, Ryoichi, Kamigaki, Takashi, Ku, Yonson, Tohyama, Kaoru, Tohyama, Yumi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037650/
https://ncbi.nlm.nih.gov/pubmed/21169636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.171702
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