XLF acts as a flexible connector during non-homologous end joining

Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks in vertebrates. During NHEJ DNA ends are held together by a multi-protein synaptic complex until they are ligated. Here, we use Xenopus laevis egg extract to investigate the role of the intrinsically d...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Carney, Sean M, Moreno, Andrew T, Piatt, Sadie C, Cisneros-Aguirre, Metztli, Lopezcolorado, Felicia Wednesday, Stark, Jeremy M, Loparo, Joseph J
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2020
Sujets:
Chromosomes and Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7744095/
https://ncbi.nlm.nih.gov/pubmed/33289484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61920
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