SARS-CoV-2 Nsp16 activation mechanism and a cryptic pocket with pan-coronavirus antiviral potential

Coronaviruses have caused multiple epidemics in the past two decades, in addition to the current COVID-19 pandemic that is severely damaging global health and the economy. Coronaviruses employ between twenty and thirty proteins to carry out their viral replication cycle including infection, immune e...

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Bibliographic Details
Published in:bioRxiv
Main Authors: Vithani, Neha, Ward, Michael D., Zimmerman, Maxwell I., Novak, Borna, Borowsky, Jonathan H., Singh, Sukrit, Bowman, Gregory R.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7743098/
https://ncbi.nlm.nih.gov/pubmed/33330873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.10.420109
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