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The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
The spike D614G mutation increases SARS-CoV-2 infectivity, viral load, and transmission but the molecular mechanism underlying these effects remains unclear. We report here that spike is trafficked to lysosomes and that the D614G mutation enhances the lysosomal sorting of spike and the lysosomal acc...
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| Publicado no: | bioRxiv |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7743070/ https://ncbi.nlm.nih.gov/pubmed/33330866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.12.08.417022 |
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