Spike mutation D614G alters SARS-CoV-2 fitness

A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic(1,2). However, the impact on viral spread and vaccine efficacy remains to be defined. Here, we engineer the D614G mutation in the USA-WA1/2020 strain and characterize its effect. D614G enhances replication on h...

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Publicado no:Nature
Main Authors: Plante, Jessica A., Liu, Yang, Liu, Jianying, Xia, Hongjie, Johnson, Bryan A., Lokugamage, Kumari G., Zhang, Xianwen, Muruato, Antonio E., Zou, Jing, Fontes-Garfias, Camila R., Mirchandani, Divya, Scharton, Dionna, Bilello, John P., Ku, Zhiqiang, An, Zhiqiang, Kalveram, Birte, Freiberg, Alexander N., Menachery, Vineet D., Xie, Xuping, Plante, Kenneth S., Weaver, Scott C., Shi, Pei-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158177/
https://ncbi.nlm.nih.gov/pubmed/33106671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2895-3
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