Spike mutation D614G alters SARS-CoV-2 fitness

A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic(1,2). However, the impact on viral spread and vaccine efficacy remains to be defined. Here, we engineer the D614G mutation in the USA-WA1/2020 strain and characterize its effect. D614G enhances replication on h...

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Bibliografski detalji
Izdano u:Nature
Glavni autori: Plante, Jessica A., Liu, Yang, Liu, Jianying, Xia, Hongjie, Johnson, Bryan A., Lokugamage, Kumari G., Zhang, Xianwen, Muruato, Antonio E., Zou, Jing, Fontes-Garfias, Camila R., Mirchandani, Divya, Scharton, Dionna, Bilello, John P., Ku, Zhiqiang, An, Zhiqiang, Kalveram, Birte, Freiberg, Alexander N., Menachery, Vineet D., Xie, Xuping, Plante, Kenneth S., Weaver, Scott C., Shi, Pei-Yong
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158177/
https://ncbi.nlm.nih.gov/pubmed/33106671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2895-3
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