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Spike mutation D614G alters SARS-CoV-2 fitness
A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic(1,2). However, the impact on viral spread and vaccine efficacy remains to be defined. Here, we engineer the D614G mutation in the USA-WA1/2020 strain and characterize its effect. D614G enhances replication on h...
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| Izdano u: | Nature |
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| Glavni autori: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8158177/ https://ncbi.nlm.nih.gov/pubmed/33106671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2895-3 |
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