Spike mutation D614G alters SARS-CoV-2 fitness

A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic(1,2). However, the impact on viral spread and vaccine efficacy remains to be defined. Here, we engineer the D614G mutation in the USA-WA1/2020 strain and characterize its effect. D614G enhances replication on h...

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Pubblicato in:Nature
Autori principali: Plante, Jessica A., Liu, Yang, Liu, Jianying, Xia, Hongjie, Johnson, Bryan A., Lokugamage, Kumari G., Zhang, Xianwen, Muruato, Antonio E., Zou, Jing, Fontes-Garfias, Camila R., Mirchandani, Divya, Scharton, Dionna, Bilello, John P., Ku, Zhiqiang, An, Zhiqiang, Kalveram, Birte, Freiberg, Alexander N., Menachery, Vineet D., Xie, Xuping, Plante, Kenneth S., Weaver, Scott C., Shi, Pei-Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158177/
https://ncbi.nlm.nih.gov/pubmed/33106671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2895-3
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