Boiling histotripsy and in-situ CD40 stimulation improve the checkpoint blockade therapy of poorly immunogenic tumors

Background: Advanced stage cancers with a suppressive tumor microenvironment (TME) are often refractory to immune checkpoint inhibitor (ICI) therapy. Recent studies have shown that focused ultrasound (FUS) TME-modulation can synergize ICI therapy, but enhancing survival outcomes in poorly immunogeni...

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Vydáno v:Theranostics
Hlavní autoři: Singh, Mohit Pratap, Sethuraman, Sri Nandhini, Miller, Craig, Malayer, Jerry, Ranjan, Ashish
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738858/
https://ncbi.nlm.nih.gov/pubmed/33391491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.49517
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