Hexosamine biosynthetic pathway promotes the antiviral activity of SAMHD1 by enhancing O-GlcNAc transferase-mediated protein O-GlcNAcylation

Rationale: Viruses hijack the host cell machinery to promote viral replication; however, the mechanism by which metabolic reprogramming regulates innate antiviral immunity in the host remains elusive. Herein, we explore how the hexosamine biosynthesis pathway (HBP) and O-linked-N-acetylglucosaminyla...

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Udgivet i:Theranostics
Main Authors: Hu, Jie, Gao, Qingzhu, Yang, Yang, Xia, Jie, Zhang, Wanjun, Chen, Yao, Zhou, Zhi, Chang, Lei, Hu, Yuan, Zhou, Hui, Liang, Li, Li, Xiaosong, Long, Quanxin, Wang, Kai, Huang, Ailong, Tang, Ni
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738853/
https://ncbi.nlm.nih.gov/pubmed/33391506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.50230
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