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Profilin’s affinity for formin regulates the availability of filament ends for actin monomer binding
Nucleation-promoting proteins tightly regulate actin polymerization in cells. Whereas many of these proteins bind actin monomers directly, formins use the actin-binding protein profilin to dynamically load actin monomers onto their flexible Formin Homology 1 (FH1) domains. Following binding, FH1 dom...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7738411/ https://ncbi.nlm.nih.gov/pubmed/33289668 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.10.022 |
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