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Profilin’s affinity for formin regulates the availability of filament ends for actin monomer binding

Nucleation-promoting proteins tightly regulate actin polymerization in cells. Whereas many of these proteins bind actin monomers directly, formins use the actin-binding protein profilin to dynamically load actin monomers onto their flexible Formin Homology 1 (FH1) domains. Following binding, FH1 dom...

詳細記述

保存先:
書誌詳細
出版年:J Mol Biol
主要な著者: Zweifel, Mark E., Courtemanche, Naomi
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738411/
https://ncbi.nlm.nih.gov/pubmed/33289668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.10.022
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