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Competition for delivery of profilin–actin to barbed ends limits the rate of formin-mediated actin filament elongation

Formins direct the elongation of unbranched actin filaments by binding their barbed ends and processively stepping onto incoming actin monomers to incorporate them into the filament. Binding of profilin to actin monomers creates profilin–actin complexes, which then bind polyproline tracts located in...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Zweifel, Mark E., Courtemanche, Naomi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135983/
https://ncbi.nlm.nih.gov/pubmed/32075907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012000
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