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Competition for delivery of profilin–actin to barbed ends limits the rate of formin-mediated actin filament elongation

Formins direct the elongation of unbranched actin filaments by binding their barbed ends and processively stepping onto incoming actin monomers to incorporate them into the filament. Binding of profilin to actin monomers creates profilin–actin complexes, which then bind polyproline tracts located in...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Zweifel, Mark E., Courtemanche, Naomi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135983/
https://ncbi.nlm.nih.gov/pubmed/32075907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012000
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