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Competition for delivery of profilin–actin to barbed ends limits the rate of formin-mediated actin filament elongation

Formins direct the elongation of unbranched actin filaments by binding their barbed ends and processively stepping onto incoming actin monomers to incorporate them into the filament. Binding of profilin to actin monomers creates profilin–actin complexes, which then bind polyproline tracts located in...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Zweifel, Mark E., Courtemanche, Naomi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7135983/
https://ncbi.nlm.nih.gov/pubmed/32075907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012000
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