Polygenic Score for Beta-Blocker Survival Benefit in European Ancestry Patients with Reduced Ejection Fraction Heart Failure

BACKGROUND: Beta-blockers (BB) are mainstay therapy for heart failure with reduced ejection fraction (HFrEF). However, individual patient responses to BB vary, which may be partially due to genetic variation. The goal of this study was to derive and validate the first polygenic response predictor (P...

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Publicado en:Circ Heart Fail
Main Authors: Lanfear, David E., Luzum, Jasmine A., She, Ruicong, Gui, Hongsheng, Donahue, Mark P., O’Connor, Christopher M., Adams, Kirkwood F., Sanders-van Wijk, Sandra, Zeld, Nicole, Maeder, Micha T., Sabbah, Hani N., Kraus, William E., Brunner-LaRocca, Hans-Peter, Li, Jia, Williams, L. Keoki
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738407/
https://ncbi.nlm.nih.gov/pubmed/33012170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.007012
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