Polygenic Score for Beta-Blocker Survival Benefit in European Ancestry Patients with Reduced Ejection Fraction Heart Failure

BACKGROUND: Beta-blockers (BB) are mainstay therapy for heart failure with reduced ejection fraction (HFrEF). However, individual patient responses to BB vary, which may be partially due to genetic variation. The goal of this study was to derive and validate the first polygenic response predictor (P...

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Bibliografski detalji
Izdano u:Circ Heart Fail
Glavni autori: Lanfear, David E., Luzum, Jasmine A., She, Ruicong, Gui, Hongsheng, Donahue, Mark P., O’Connor, Christopher M., Adams, Kirkwood F., Sanders-van Wijk, Sandra, Zeld, Nicole, Maeder, Micha T., Sabbah, Hani N., Kraus, William E., Brunner-LaRocca, Hans-Peter, Li, Jia, Williams, L. Keoki
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738407/
https://ncbi.nlm.nih.gov/pubmed/33012170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.007012
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