Polygenic Score for Beta-Blocker Survival Benefit in European Ancestry Patients with Reduced Ejection Fraction Heart Failure

BACKGROUND: Beta-blockers (BB) are mainstay therapy for heart failure with reduced ejection fraction (HFrEF). However, individual patient responses to BB vary, which may be partially due to genetic variation. The goal of this study was to derive and validate the first polygenic response predictor (P...

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書誌詳細
出版年:Circ Heart Fail
主要な著者: Lanfear, David E., Luzum, Jasmine A., She, Ruicong, Gui, Hongsheng, Donahue, Mark P., O’Connor, Christopher M., Adams, Kirkwood F., Sanders-van Wijk, Sandra, Zeld, Nicole, Maeder, Micha T., Sabbah, Hani N., Kraus, William E., Brunner-LaRocca, Hans-Peter, Li, Jia, Williams, L. Keoki
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738407/
https://ncbi.nlm.nih.gov/pubmed/33012170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.119.007012
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