Effects of Open-Label, Adjunctive Ganaxolone on Persistent Depression Despite Adequate Antidepressant Treatment in Postmenopausal Women: A Pilot Study

OBJECTIVE: The neuroactive steroid metabolite of progesterone, allopregnanolone, is a positive allosteric modulator of GABA(A) receptors and a putative treatment for mood disorders. We performed a pilot study to determine whether an oral allopregnanolone analog (ganaxolone) may be effective adjuncti...

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Pubblicato in:J Clin Psychiatry
Autori principali: Dichtel, Laura E., Nyer, Maren, Dording, Christina, Fisher, Lauren B., Cusin, Cristina, Shapero, Benjamin G., Pedrelli, Paola, Kimball, Allison S., Rao, Elizabeth M., Mischoulon, David, Fava, Maurizio, Miller, Karen K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738196/
https://ncbi.nlm.nih.gov/pubmed/32558402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4088/JCP.19m12887
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