Effects of Open-Label, Adjunctive Ganaxolone on Persistent Depression Despite Adequate Antidepressant Treatment in Postmenopausal Women: A Pilot Study

OBJECTIVE: The neuroactive steroid metabolite of progesterone, allopregnanolone, is a positive allosteric modulator of GABA(A) receptors and a putative treatment for mood disorders. We performed a pilot study to determine whether an oral allopregnanolone analog (ganaxolone) may be effective adjuncti...

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Detaylı Bibliyografya
Yayımlandı:J Clin Psychiatry
Asıl Yazarlar: Dichtel, Laura E., Nyer, Maren, Dording, Christina, Fisher, Lauren B., Cusin, Cristina, Shapero, Benjamin G., Pedrelli, Paola, Kimball, Allison S., Rao, Elizabeth M., Mischoulon, David, Fava, Maurizio, Miller, Karen K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7738196/
https://ncbi.nlm.nih.gov/pubmed/32558402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4088/JCP.19m12887
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