In Vitro Profiling of Laninamivir-Resistant Substitutions in N3 to N9 Avian Influenza Virus Neuraminidase Subtypes and Their Association with In Vivo Susceptibility

Laninamivir (LAN) is a long-acting neuraminidase (NA) inhibitor (NAI) with a similar binding profile in the influenza NA enzyme active site as those of other NAIs, oseltamivir (OS), zanamivir (ZAN), and peramivir, and may share common resistance markers with these NAIs. We screened viruses with NA s...

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Publicado en:J Virol
Autores principales: Jeong, Ju Hwan, Choi, Won-Suk, Antigua, Khristine Joy C., Choi, Young Ki, Govorkova, Elena A., Webby, Richard J., Baek, Yun Hee, Song, Min-Suk
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2020
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737746/
https://ncbi.nlm.nih.gov/pubmed/33055248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01679-20
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