PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range

Adaptive mutations and/or reassortments in avian influenza virus polymerase subunits PA, PB1, and PB2 are one of the major factors enabling the virus to overcome the species barrier to infect humans. The majority of human adaptation polymerase mutations have been identified in PB2; fewer adaptation...

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Bibliografiska uppgifter
I publikationen:J Virol
Huvudupphovsmän: Arai, Yasuha, Kawashita, Norihito, Elgendy, Emad Mohamed, Ibrahim, Madiha Salah, Daidoji, Tomo, Ono, Takao, Takagi, Tatsuya, Nakaya, Takaaki, Matsumoto, Kazuhiko, Watanabe, Yohei
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2020
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737735/
https://ncbi.nlm.nih.gov/pubmed/33028722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01582-20
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