Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

A major determinant in the change of the avian influenza virus host range to humans is the E627K substitution in the PB2 polymerase protein. However, the polymerase activity of avian influenza viruses with a single PB2-E627K mutation is still lower than that of seasonal human influenza viruses, impl...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Arai, Yasuha, Kawashita, Norihito, Daidoji, Tomo, Ibrahim, Madiha S., El-Gendy, Emad M., Takagi, Tatsuya, Takahashi, Kazuo, Suzuki, Yasuo, Ikuta, Kazuyoshi, Nakaya, Takaaki, Shioda, Tatsuo, Watanabe, Yohei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838241/
https://ncbi.nlm.nih.gov/pubmed/27097026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005583
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker