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Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

A major determinant in the change of the avian influenza virus host range to humans is the E627K substitution in the PB2 polymerase protein. However, the polymerase activity of avian influenza viruses with a single PB2-E627K mutation is still lower than that of seasonal human influenza viruses, impl...

詳細記述

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書誌詳細
出版年:PLoS Pathog
主要な著者: Arai, Yasuha, Kawashita, Norihito, Daidoji, Tomo, Ibrahim, Madiha S., El-Gendy, Emad M., Takagi, Tatsuya, Takahashi, Kazuo, Suzuki, Yasuo, Ikuta, Kazuyoshi, Nakaya, Takaaki, Shioda, Tatsuo, Watanabe, Yohei
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838241/
https://ncbi.nlm.nih.gov/pubmed/27097026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005583
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