Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

A major determinant in the change of the avian influenza virus host range to humans is the E627K substitution in the PB2 polymerase protein. However, the polymerase activity of avian influenza viruses with a single PB2-E627K mutation is still lower than that of seasonal human influenza viruses, impl...

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Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Arai, Yasuha, Kawashita, Norihito, Daidoji, Tomo, Ibrahim, Madiha S., El-Gendy, Emad M., Takagi, Tatsuya, Takahashi, Kazuo, Suzuki, Yasuo, Ikuta, Kazuyoshi, Nakaya, Takaaki, Shioda, Tatsuo, Watanabe, Yohei
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838241/
https://ncbi.nlm.nih.gov/pubmed/27097026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005583
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