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Formation of Monofluorinated Radical Cofactor in Galactose Oxidase through Copper-Mediated C−F Bond Scission

Galactose oxidase (GAO) contains a Cu(II)-ligand radical cofactor. The cofactor, which is autocatalytically generated through the oxidation of the copper, consists of a cysteine-tyrosine radical (Cys-Tyr(•)) as a copper ligand. The formation of the crosslinked thioether bond is accompanied by a C-H...

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Bibliografische gegevens
Gepubliceerd in:J Am Chem Soc
Hoofdauteurs: Li, Jiasong, Davis, Ian, Griffith, Wendell P., Liu, Aimin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737484/
https://ncbi.nlm.nih.gov/pubmed/33091303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c08992
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