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Probing the Tyr-Cys Cofactor Biogenesis in Cysteine Dioxygenase by the Genetic Incorporation of Fluorotyrosine

Cysteine dioxygenase (CDO) is a non-heme iron enzyme that adds two oxygen atoms from dioxygen to the sulfur atom of L-cysteine. Adjacent to the iron site of mammalian CDO, a post-translationally generated Cys-Tyr cofactor is present, whose presence substantially enhances the oxygenase activity. The...

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Библиографические подробности
Опубликовано в: :Biochemistry
Главные авторы: Li, Jiasong, Koto, Teruaki, Davis, Ian, Liu, Aimin
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658890/
https://ncbi.nlm.nih.gov/pubmed/30946568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00006
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