Structure-based insights into the role of the Cys-Tyr crosslink and inhibitor-recognition by Mammalian Cysteine Dioxygenase

In mammals, the non-heme iron enzyme cysteine dioxygenase (CDO) helps regulate cysteine (Cys) levels through converting Cys to cysteine sulfinic acid (CSA). Its activity is in part modulated by the formation of a Cys93-Tyr157 crosslink that increases its catalytic efficiency over 10-fold. Here, 21 h...

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Publicado en:J Mol Biol
Main Authors: Driggers, Camden M., Kean, Kelsey M., Hirschberger, Lawrence L., Cooley, Richard B., Stipanuk, Martha H., Karplus, P. Andrew
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048534/
https://ncbi.nlm.nih.gov/pubmed/27477048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.07.012
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