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Structure-based insights into the role of the Cys-Tyr crosslink and inhibitor-recognition by Mammalian Cysteine Dioxygenase
In mammals, the non-heme iron enzyme cysteine dioxygenase (CDO) helps regulate cysteine (Cys) levels through converting Cys to cysteine sulfinic acid (CSA). Its activity is in part modulated by the formation of a Cys93-Tyr157 crosslink that increases its catalytic efficiency over 10-fold. Here, 21 h...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5048534/ https://ncbi.nlm.nih.gov/pubmed/27477048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.07.012 |
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