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Quantifying the Relationship between Conformational Dynamics and Enzymatic Activity in Ribonuclease HI Homologues
Ribonuclease HI (RNHI), a ubiquitous, non-sequence-specific endonuclease, cleaves the RNA strand in RNA/DNA hybrids. RNHI functions in replication, genome maintenance, and retroviral reverse transcriptases contain an essential ribonuclease H domain. NMR spectroscopy combined with molecular dynamics...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7737441/ https://ncbi.nlm.nih.gov/pubmed/32813972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00500 |
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