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A Cas9-mediated adenosine transient reporter enables enrichment of ABE-targeted cells
BACKGROUND: Adenine base editors (ABE) enable single nucleotide modifications without the need for double-stranded DNA breaks (DSBs) induced by conventional CRIPSR/Cas9-based approaches. However, most approaches that employ ABEs require inefficient downstream technologies to identify desired targete...
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| Publié dans: | BMC Biol |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7737295/ https://ncbi.nlm.nih.gov/pubmed/33317513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00929-7 |
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