A Cas9-mediated adenosine transient reporter enables enrichment of ABE-targeted cells

BACKGROUND: Adenine base editors (ABE) enable single nucleotide modifications without the need for double-stranded DNA breaks (DSBs) induced by conventional CRIPSR/Cas9-based approaches. However, most approaches that employ ABEs require inefficient downstream technologies to identify desired targete...

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Bibliographic Details
Published in:BMC Biol
Main Authors: Brookhouser, Nicholas, Nguyen, Toan, Tekel, Stefan J., Standage-Beier, Kylie, Wang, Xiao, Brafman, David A.
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7737295/
https://ncbi.nlm.nih.gov/pubmed/33317513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00929-7
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