Screening for functional transcriptional and splicing regulatory variants with GenIE

Genome-wide association studies (GWAS) have identified numerous genetic loci underlying human diseases, but a fundamental challenge remains to accurately identify the underlying causal genes and variants. Here, we describe an arrayed CRISPR screening method, Genome engineering-based Interrogation of...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Cooper, Sarah E, Schwartzentruber, Jeremy, Bello, Erica, Coomber, Eve L, Bassett, Andrew R
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
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Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736817/
https://ncbi.nlm.nih.gov/pubmed/33152068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa960
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