Ca(2+) Dependence of Volume-Regulated VRAC/LRRC8 and TMEM16A Cl(–) Channels

All vertebrate cells activate Cl(–) currents (I(Cl)(,swell)) when swollen by hypotonic bath solution. The volume-regulated anion channel VRAC has now been identified as LRRC8/SWELL1. However, apart from VRAC, the Ca(2+)-activated Cl(–) channel (CaCC) TMEM16A and the phospholipid scramblase and ion c...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Centeio, Raquel, Ousingsawat, Jiraporn, Schreiber, Rainer, Kunzelmann, Karl
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736618/
https://ncbi.nlm.nih.gov/pubmed/33335902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.596879
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