Epigenetic Reader BRD4 Governs Nucleus-encoded Mitochondrial Transcriptome to Regulate Cardiac Function

BACKGROUND: BET (Bromodomain and Extra-Terminal) epigenetic reader proteins, in particular BRD4, have emerged as potential therapeutic targets in a number of pathological conditions, including cancer and cardiovascular disease. Small molecule BET protein inhibitors, such as JQ1, have demonstrated ef...

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Veröffentlicht in:Circulation
Hauptverfasser: Kim, Soo Young, Zhang, Xin, Schiattarella, Gabriele G., Altamirano, Francisco, Ramos, Thais A. R., French, Kristin M., Jiang, Nan, Szweda, Pamela A., Evers, Bret M., May, Herman I., Luo, Xiang, Li, Hongliang, Szweda, Luke I., Maracaja-Coutinho, Vinicius, Lavandero, Sergio, Gillette, Thomas G., Hill, Joseph A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736324/
https://ncbi.nlm.nih.gov/pubmed/33113340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.047239
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