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A modular template for the design of thiol-triggered sensors and prodrugs

A unique reaction between thiols (RSH) and alkyl sulfonylbenzothiazole was discovered. This reaction was specific for thiols and produced a sulfinic acid (RSO(2)H) as the intermediate, which further triggered an intramolecular cyclization to release a -OH containing payload. This reaction was used t...

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Detalhes bibliográficos
Publicado no:Spectrochim Acta A Mol Biomol Spectrosc
Main Authors: Knight, Jessica Renee, Wang, Yingying, Xu, Shi, Chen, Wei, Berkman, Clifford E., Xian, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7736145/
https://ncbi.nlm.nih.gov/pubmed/33128946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.saa.2020.119072
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