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Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR
[Image: see text] Candidate drugs rationally designed in vitro often fail due to low efficacy in vivo caused by low tissue availability or because of unwanted side effects. To overcome the limitations of in vitro rational drug design, the binding of candidate drugs to their target needs to be evalua...
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| Pubblicato in: | ACS Chem Biol |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2020
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7735671/ https://ncbi.nlm.nih.gov/pubmed/32955851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00590 |
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