Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR

[Image: see text] Candidate drugs rationally designed in vitro often fail due to low efficacy in vivo caused by low tissue availability or because of unwanted side effects. To overcome the limitations of in vitro rational drug design, the binding of candidate drugs to their target needs to be evalua...

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Bibliografiske detaljer
Udgivet i:ACS Chem Biol
Main Authors: Luchinat, Enrico, Barbieri, Letizia, Cremonini, Matteo, Nocentini, Alessio, Supuran, Claudiu T., Banci, Lucia
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735671/
https://ncbi.nlm.nih.gov/pubmed/32955851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00590
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