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Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency
Structure‐based drug development is often hampered by the lack of in vivo activity of promising compounds screened in vitro, due to low membrane permeability or poor intracellular binding selectivity. Herein, we show that ligand screening can be performed in living human cells by “intracellular prot...
Sparad:
| I publikationen: | Angew Chem Int Ed Engl |
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| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
John Wiley and Sons Inc.
2020
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7187179/ https://ncbi.nlm.nih.gov/pubmed/32022355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201913436 |
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