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Drug Screening in Human Cells by NMR Spectroscopy Allows the Early Assessment of Drug Potency

Structure‐based drug development is often hampered by the lack of in vivo activity of promising compounds screened in vitro, due to low membrane permeability or poor intracellular binding selectivity. Herein, we show that ligand screening can be performed in living human cells by “intracellular prot...

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Bibliografiska uppgifter
I publikationen:Angew Chem Int Ed Engl
Huvudupphovsmän: Luchinat, Enrico, Barbieri, Letizia, Cremonini, Matteo, Nocentini, Alessio, Supuran, Claudiu T., Banci, Lucia
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7187179/
https://ncbi.nlm.nih.gov/pubmed/32022355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201913436
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