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Real-Time Quantitative In-Cell NMR: Ligand Binding and Protein Oxidation Monitored in Human Cells Using Multivariate Curve Resolution

[Image: see text] In-cell NMR can investigate protein conformational changes at atomic resolution, such as those changes induced by drug binding or chemical modifications, directly in living human cells, and therefore has great potential in the context of drug development as it can provide an early...

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Bibliografische gegevens
Gepubliceerd in:Anal Chem
Hoofdauteurs: Luchinat, Enrico, Barbieri, Letizia, Campbell, Timothy F., Banci, Lucia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2020
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735651/
https://ncbi.nlm.nih.gov/pubmed/32551584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c01677
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