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Real-Time Quantitative In-Cell NMR: Ligand Binding and Protein Oxidation Monitored in Human Cells Using Multivariate Curve Resolution

[Image: see text] In-cell NMR can investigate protein conformational changes at atomic resolution, such as those changes induced by drug binding or chemical modifications, directly in living human cells, and therefore has great potential in the context of drug development as it can provide an early...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Luchinat, Enrico, Barbieri, Letizia, Campbell, Timothy F., Banci, Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7735651/
https://ncbi.nlm.nih.gov/pubmed/32551584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c01677
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