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Structure-based design and discovery of a long-acting cocaine hydrolase mutant with improved binding affinity to neonatal Fc receptor for treatment of cocaine abuse
Despite decades of efforts to develop a pharmacotherapy for cocaine abuse treatment, there is still no FDA-approved treatments of diseases associated with this commonly-abused drug. Our previously designed highly efficient cocaine hydrolases (CocHs) and the corresponding Fc-fusion proteins (e.g. Coc...
Enregistré dans:
| Publié dans: | AAPS J |
|---|---|
| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7735386/ https://ncbi.nlm.nih.gov/pubmed/32189158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-020-00442-3 |
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