XRCC4 rs28360071 intronic variant is associated with increased risk for infant acute lymphoblastic leukemia with KMT2A rearrangements

Early age acute leukemia (EAL) shows a high frequency of KMT2A-rearrangements (KMT2A-r). Previous investigations highlighted double-strand breaks arising from maternal exposure to xenobiotics during pregnancy as a risk factor for EAL and KMT2A-r. In this case-control study, we investigated the relat...

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Dades bibliogràfiques
Publicat a:Genet Mol Biol
Autors principals: Louzada-Neto, Orlando, Lopes, Bruno A., Brisson, Gisele D., Andrade, Francianne G., Cezar, Ingrid S., Santos-Rebouças, Cíntia B., Albano, Rodolpho M., Pombo-de-Oliveira, Maria S., Rossini, Ana
Format: Artigo
Idioma:Inglês
Publicat: Sociedade Brasileira de Genética 2020
Matèries:
Human and Medical Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734917/
https://ncbi.nlm.nih.gov/pubmed/33270074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/1678-4685-GMB-2020-0160
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