Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

BACKGROUND: Infants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The ai...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Cheung, Laurence C., de Kraa, Rebecca, Oommen, Joyce, Chua, Grace-Alyssa, Singh, Sajla, Hughes, Anastasia M., Ferrari, Emanuela, Ford, Jette, Chiu, Sung K., Stam, Ronald W., Kees, Ursula R., Malinge, Sébastien, Kotecha, Rishi S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082024/
https://ncbi.nlm.nih.gov/pubmed/33937032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.631594
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