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Management of pharmaceutical ICH M7 (Q)SAR predictions – The impact of model updates
Pharmaceutical applicants conduct (Q)SAR assessments on identified and theoretical impurities to predict their mutagenic potential. Two complementary models—one rule-based and one statistical-based—are used, followed by expert review. (Q)SAR models are continuously updated to improve predictions, wi...
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| 出版年: | Regul Toxicol Pharmacol |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7734868/ https://ncbi.nlm.nih.gov/pubmed/33058939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yrtph.2020.104807 |
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