Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo

BACKGROUND: The paracrine effects of multipotent mesenchymal stromal cells (MSCs) are mediated by their secretome composed by soluble factors (i.e., cytokines, growth factors, hormones) and extracellular vesicles (EVs). EVs promote intercellular communication, and the EV cargoes [e.g., proteins, sol...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Cheng, Anastasia, Choi, Dongsic, Lora, Maximilien, Shum-Tim, Dominique, Rak, Janusz, Colmegna, Inés
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734842/
https://ncbi.nlm.nih.gov/pubmed/33317598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02050-6
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