Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo

BACKGROUND: The paracrine effects of multipotent mesenchymal stromal cells (MSCs) are mediated by their secretome composed by soluble factors (i.e., cytokines, growth factors, hormones) and extracellular vesicles (EVs). EVs promote intercellular communication, and the EV cargoes [e.g., proteins, sol...

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Vydáno v:Stem Cell Res Ther
Hlavní autoři: Cheng, Anastasia, Choi, Dongsic, Lora, Maximilien, Shum-Tim, Dominique, Rak, Janusz, Colmegna, Inés
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734842/
https://ncbi.nlm.nih.gov/pubmed/33317598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02050-6
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