Mutational Analysis of Ocriplasmin to Reduce Proteolytic and Autolytic Activity in Pichia pastoris

BACKGROUND: Ocriplasmin (Jetrea) is using for the treatment of symptomatic vitreomacular adhesion. This enzyme undergoes rapid inactivation and limited activity duration as a result of its autolytic nature after injection within the eye. Moreover, the proteolytic activity can cause photoreceptor dam...

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Publicado en:Biol Proced Online
Autores principales: Baghban, Roghayyeh, Farajnia, Safar, Ghasemi, Younes, Hoseinpoor, Reyhaneh, Safary, Azam, Mortazavi, Mojtaba, Zarghami, Nosratollah
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734836/
https://ncbi.nlm.nih.gov/pubmed/33308171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12575-020-00138-0
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