Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115

Human serum albumin (HSA) and human parathyroid hormone (1-34) [PTH (1-34)] fusion protein [HSA/PTH (1-34)] is a promising long-acting form of PTH (1-34) for osteoporosis treatment. Secretory expression of intact HSA/PTH (1-34) in Pichia pastoris GS115 was accompanied by two degradation fragments, w...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Wu, Min, Shen, Qi, Yang, Yong, Zhang, Sheng, Qu, Wen, Chen, Jing, Sun, Hongying, Chen, Shuqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer-Verlag 2013
Soggetti:
Biotechnology Methods
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656227/
https://ncbi.nlm.nih.gov/pubmed/23529666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10295-013-1264-8
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi