Semisynthetic Analogs of the Antibiotic Fidaxomicin—Design, Synthesis, and Biological Evaluation

[Image: see text] The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good to excellent activity against Gram-positive bacteria and was approved for the treatment of Clostridium difficile infections (CDI). Among the main limitations for this compound, its lo...

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Publicat a:ACS Med Chem Lett
Autors principals: Dorst, Andrea, Berg, Regina, Gertzen, Christoph G. W., Schäfle, Daniel, Zerbe, Katja, Gwerder, Myriam, Schnell, Simon D., Sander, Peter, Gohlke, Holger, Gademann, Karl
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734799/
https://ncbi.nlm.nih.gov/pubmed/33329763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00381
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