Semisynthetic Analogs of the Antibiotic Fidaxomicin—Design, Synthesis, and Biological Evaluation

[Image: see text] The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good to excellent activity against Gram-positive bacteria and was approved for the treatment of Clostridium difficile infections (CDI). Among the main limitations for this compound, its lo...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:ACS Med Chem Lett
Autori principali: Dorst, Andrea, Berg, Regina, Gertzen, Christoph G. W., Schäfle, Daniel, Zerbe, Katja, Gwerder, Myriam, Schnell, Simon D., Sander, Peter, Gohlke, Holger, Gademann, Karl
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734799/
https://ncbi.nlm.nih.gov/pubmed/33329763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00381
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi