Dual-Stage Picolinic Acid-Derived Inhibitors of Toxoplasma gondii

[Image: see text] Toxoplasma gondii causes a prevalent human infection for which only the acute stage has an FDA-approved therapy. To find inhibitors of both the acute stage parasites and the persistent cyst stage that causes a chronic infection, we repurposed a compound library containing known inh...

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Udgivet i:ACS Med Chem Lett
Main Authors: Khalifa, Muhammad M., Martorelli Di Genova, Bruno, McAlpine, Sarah G., Gallego-Lopez, Gina M., Stevenson, David M., Rozema, Soren D., Monaghan, Neil P., Morris, James C., Knoll, Laura J., Golden, Jennifer E.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734631/
https://ncbi.nlm.nih.gov/pubmed/33335660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00267
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