The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation

Kinases use ATP to phosphorylate substrates; recent findings underscore the additional regulatory roles of ATP. Here, we propose a mechanism for allosteric regulation of Akt1 kinase phosphorylation by ATP. Our 4.7-μs molecular dynamics simulations of Akt1 and its mutants in the ATP/ADP bound/unbound...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Lu, Shaoyong, Deng, Rong, Jiang, Haiming, Song, Huili, Li, Shuai, Shen, Qiancheng, Huang, Wenkang, Nussinov, Ruth, Yu, Jianxiu, Zhang, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734571/
https://ncbi.nlm.nih.gov/pubmed/26256536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.06.027
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