The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides

Plasmodium parasites rely heavily on glycolysis for ATP production and for precursors for essential anabolic pathways, such as the methylerythritol phosphate (MEP) pathway. Here, we show that mutations in the Plasmodium falciparum glycolytic enzyme, phosphofructokinase (PfPFK9), are associated with...

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Bibliographic Details
Published in:mBio
Main Authors: Fisher, Gillian M., Cobbold, Simon A., Jezewski, Andrew, Carpenter, Emma F., Arnold, Megan, Cowell, Annie N., Tjhin, Erick T., Saliba, Kevin J., Skinner-Adams, Tina S., Lee, Marcus C. S., Odom John, Audrey, Winzeler, Elizabeth A., McConville, Malcolm J., Poulsen, Sally-Ann, Andrews, Katherine T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733947/
https://ncbi.nlm.nih.gov/pubmed/33293381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02842-20
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