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KRAB zinc finger protein diversification drives mammalian interindividual methylation variability

Most transposable elements (TEs) in the mouse genome are heavily modified by DNA methylation and repressive histone modifications. However, a subset of TEs exhibit variable methylation levels in genetically identical individuals, and this is associated with epigenetically conferred phenotypic differ...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Bertozzi, Tessa M., Elmer, Jessica L., Macfarlan, Todd S., Ferguson-Smith, Anne C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733849/
https://ncbi.nlm.nih.gov/pubmed/33239447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017053117
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