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Human iNSC-derived brain organoid model of lysosomal storage disorder in Niemann–Pick disease type C

Recent studies on developing three-dimensional (3D) brain organoids from stem cells have allowed the generation of in vitro models of neural disease and have enabled the screening of drugs because these organoids mimic the complexity of neural tissue. Niemann-Pick disease, type C (NPC) is a neurodeg...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Lee, Seung-Eun, Shin, Nari, Kook, Myung Geun, Kong, Dasom, Kim, Nam Gyo, Choi, Soon Won, Kang, Kyung-Sun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733597/
https://ncbi.nlm.nih.gov/pubmed/33311479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03262-7
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