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Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs
A chiral synthesis of a series of hexahydroisobenzofuran (HIBF) nucleosides has been accomplished via glycosylation of a stereo-defined (syn-isomer) sugar motif 16 with the appropriate silylated bases. All nucleoside analogs were obtained in 52–71% yield as a mixture of α- and β-anomeric products in...
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| Publié dans: | Org Biomol Chem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7733237/ https://ncbi.nlm.nih.gov/pubmed/19300828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b818707j |
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